Boston Biochem

Ubiquitin Proteasome Pathway (UPP) products and services

Boston Biochem, Inc. is the world’s leading producer of Ubiquitin Proteasome Pathway (UPP) products and services, specialising in several related product lines for ubiquitin and ubiquitin-like (UBL) proteins (eg. Apg8, FAT10, ISG15, NEDD8, SUMO, UFM1) and associated enzymes, substrates, inhibitors and kits.

The Ubiquitin Proteasome Pathway (UPP) is the principal mechanism for protein catabolism in the mammalian cytosol and nucleus. The highly regulated UPP affects a wide variety of cellular processes and substrates and defects in the system can result in the pathogenesis of several important human diseases. The central role of the UPP in biology has been recognised with the Nobel Prize for Chemistry which was awarded to Avram Hershko, Aaron Ciechanover and Irwin Rose in 2004.

The UPP is central to the regulation of almost all cellular processes.

Ubiquitin Proteasome Pathway (UPP) Overviews

• E1 Activating Enzymes
• E2 Conjugating Enzymes
• E3 Ligases
• Deconjugating
• Proteasome
• Ubiquitin
• SUMO
• NEDD8
• ISG15
• UFM1
• Autophagy
• FAT10
• Antibodies
• Kits
• Buffers, Solutions, Standards
• Conjugation Control Proteins and Peptides
• Affinity Matrices / Proteins
• Fractions

References

• Boston Biochem References for Product Use

Products

Since their founding in 1997, the mission of Boston Biochem has been to provide customers with innovative reagents that facilitate and accelerate their research and drug discovery efforts. Their specialised reagents are developed, produced and characterised in-house with a strong commitment to quality. Boston Biochem constantly develop new products that keep current with the discoveries and research requirements of the extended ubiquitin-related community. In addition, they provide personalised and knowledgeable customer and technical services to support their product line.

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